The Journal of Obstetrics and Gynaecology of India
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VOL. 73 NUMBER 6 November-December  2023

Ovarian Carcinosarcoma: Rare Histology Which Never Fails to be Aggressive

Aparajita

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Introduction Ovarian carcinosarcoma constitutes 1-4% of all ovarian cancers. The more common site of sarcoma in the pelvis is the uterus. In this paper, we are reporting a case of ovarian carcinosarcoma along with a brief literature review on this aggressive disease. Our case was initially operated at non- oncology centre and referred to us after incomplete surgery.

Case details A 44 year old non- hypertensive and non- diabetic nulliparous female presented to outpatient department with history of sub-total hysterectomy and right oophorectomy done for ovarian tumour at peripheral hospital one month back. Histopathological examination showed malignant spindle neoplasm. Immuno-histo-chemistry was suggestive of ovarian carcinosarcoma/ mixed mullerian tumour with stromal overgrowth. The patient underwent completion surgery and with completion of cytoreduction (CC) score of zero. Final histopathological examination revealed it to be a stage IIIC disease with intra-abdominal metastasis. The patient completed platinum based adjuvant chemotherapy within stipulated time. However, the disease progressed within one month of completion of chemotherapy and the patient is currently recieving second line agent.

Conclusion Given that carcinosarcoma are rare, prospective datas are lacking and case reports, series and observational studies contribute to the understanding of natural course of the disease. This case report stresses upon the need to widen our vision for the rare histologies and their timely diagnosis and appropriate management. This case also affirms the aggressive behaviour of the disease as cited in the previous literature.

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